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time 0-last AUC 0 -inf : AUC from timepoint 0 to infinity AUC 0 -90 : AUC from timepoint 090 min BMI: Body Mass Index CI: Confidence interval C last : Observed plasma concentration at the last sampling timepoint C max : Maximum observed plasma concentration ECG: Electrocardiogram GCP: Good clinical practice h: Hours HIV: Human immunodeficiency virus HPHC: Harmful and potentially harmful constituent ICH: International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use LLOQ: Lower limit of quantification LS: Least squares (mean) Max: Maximum value mg: Milligrams Min: Minimum value mmHg: Millimetre mercury MOND: Modern oral nicotine delivery NCA: Non-compartmental analysis NGP: Next generation (nicotine) product OND: Oral nicotine delivery PES: Product evaluation scale PK: Pharmacokinetic TFNP: Tobacco-free nicotine pouch THR: Tobacco harm reduction T max : Time to C max TSNA: Tobacco-specific nitrosamine T 1 /2(z) : Terminal elimination half-life SERA: Swedish Ethical Review Authority SAE: Serious adverse event SAS: Statistical Analysis System (software) SD: Standard deviation VAS: Visual analogue scale References Centers for Disease Control and Prevention (US)
Luhring Augustine, New York
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Nicotiana Rustica, sometimes known as Wild Tobacco, thuoc lao, mapacho and other regional names, is an incredibly strong variety of whole leaf tobacco with up to 9x more nicotine then other varieties of whole leaf tobacco
